The holy grail of pyrene-based surface ligands on the sensitivity of graphene-based field effect transistors

Archive ouverte : Article de revue

Mishyn, Vladyslav | Hugo, Adrien | Rodrigues, Teresa | Aspermair, Patrik | Happy, Henri | Marques, Leonel | Hurot, Charlotte | Othmen, Riadh | Bouchiat, Vincent | Boukherroub, Rabah | Knoll, Wolfgang | Szunerits, Sabine

Edité par HAL CCSD ; Royal Society of Chemistry

International audience. Graphene has received intensive research interest due to its remarkable charge mobility, and the efforts in the use of graphene-based field effect transistors (GFETs) for the sensing of biological biomarkers is on the rise. Because of the high non-specific protein adsorption on graphene, well-defined surface modification strategies have to be implemented to benefit from the excellent electronic transfer characteristics of GFET devices for specific detection of biomarkers. Surprisingly, while pyrene-based ligands are the most widely used graphene surface anchors for sensing-related applications, no systematic investigation on the reaction conditions employed and the influence of pyrene functionalities has been reported so far. As this is one of the essential steps for efficient receptor integration and sensitive sensing, by using GFET-based analysis of cardiac troponin I (cTnI) as the model compound we will show that an optimized pyrene–maleimide ligand incubation time on graphene of 2 h gives the best sensing performance. This study not only will be a guideline for researchers interested in GFET biosensors but also will hopefully allow industrial GFET development in a faster path.

Consulter en ligne

Suggestions

Du même auteur

Electrochemical and electronic detection of biomarkers in serum: a systematic comparison using aptamer-functionalized surfaces | Mishyn, Vladyslav

Electrochemical and electronic detection of biomarkers in serum: a systemat...

Archive ouverte: Article de revue

Mishyn, Vladyslav | 2022-07

International audience. Sensitive and selective detection of biomarkers in serum in a short time has a significant impact on health. The enormous clinical importance of developing reliable methods and devices for te...

Controlled covalent functionalization of a graphene-channel of a field effect transistor as an ideal platform for (bio)sensing applications | Mishyn, Vladyslav

Controlled covalent functionalization of a graphene-channel of a field effe...

Archive ouverte: Article de revue

Mishyn, Vladyslav | 2021-09-27

International audience. The controlled covalent functionalization of the graphene channel of a field effect transistor, based on interdigitated gold electrodes (source and drain), via electrochemical grafting, using...

Highly performing graphene-based field effect transistor for the differentiation between mild-moderate-severe myocardial injury | Rodrigues, Teresa

Highly performing graphene-based field effect transistor for the differenti...

Archive ouverte: Article de revue

Rodrigues, Teresa | 2022-04

International audience. Cardiovascular diseases result in millions of deaths around the globe, many of which could have been avoided if identified at an early stage. Preventive cardiovascular disease diagnostics pla...

Chargement des enrichissements...